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rpsO [2019-07-05 12:23:50]
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rpsO [2019-07-05 12:23:50]

ribosomal protein
locus
BSU16680
pI
10.00
mw
10.00 kDa
protein length
89 aa Sequence Blast
gene length
270 bp Sequence Blast
function
translation
product
ribosomal protein S15 (BS18)
essential
yes
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.4|Ribosomal proteins]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

    • Gene

    Coordinates
    1,738,941 → 1,739,210

    Phenotypes of a mutant

  • essential [Pubmed|23002217,12682299]

    • The protein

    Protein family

  • [SW|ribosomal protein] S15P family (according to Swiss-Prot)

    • Structure

  • [PDB|1A32] (''Geobacillus stearothermophilus'')
  • [PDB|3J9W] (the [SW|ribosome]) [Pubmed|25903689]

    • Expression and Regulation

    Operons

    genes
    [gene|EC5D3ECF361C7CDEB606284F5E17243CD926989E|rpsO]
    description
    [Pubmed|19633085]

    regulatory mechanism

  • [regulon|stringent response|stringent response]: negative regulation, in [regulon|stringent response|stringent response]

    • regulation

  • translational repression of ''rpsO'' expression upon binding of excess [protein|EC5D3ECF361C7CDEB606284F5E17243CD926989E|RpsO] to a [SW|RNA switch] in the untranslated region of the ''rpsO'' mRNA [Pubmed|23611891,16005889]

    • additional information

  • the mRNA is processed, this is initiated by [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y] and cleavage products are subsequently subject to exonucleolytic degradation by RNases [protein|3EB289D0F58A58C693AB588798EE66A731341999|J1] and [protein|B73CE26E7AEFACFA82C67F3E7DBBB3F766F739CA|J2] and by [protein|64C6D783FF3F41C81B216F798A1DC8071345B1ED|PNPase] [PubMed|20418391]
  • the [SW|RNA switch] RNA is degraded by [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y] [pubmed|29794222]
    • view in new tab

    genes
    [gene|85E732993186528CF58FECFFE89C8F39D278F28D|ribC]-[gene|EC5D3ECF361C7CDEB606284F5E17243CD926989E|rpsO]
    description
    [Pubmed|22383849]
    view in new tab

    References

  • 19633085,19653700,20418391,10497132,11846555,23002217,16005889,23611891,25903689,27580716,29794222